The mechanism of action is not fully
understood; However, Alprazolam is readily absorbed from the
gastrointestinal tract. The peak plasma concentration is
achieved in 1-2 hours. Most of the drug is bound to plasma
protein, mainly albumin. Alprazolam is hydroxylated in the
liver to ?-hydroxyalprazolam, which is also
pharmacologically active. This and other metabolites are
later excreted in urine as glucuronides. Some of the drug is
also excreted in unchanged form.
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